March 24, 2004

Coming Attractions

I'll be away for a few days (starting fairly soon), and I may even be completely unable to access the 'net. Since I don't have time to do one of my long, fact-ridden articles, it occurred to me to do something that I haven't done before. I'll tell you what's on my slate for the future of the site. Not that people use slate anymore, but a Notepad window makes a fine substitute.

You may have noticed that I will often end an entry with an allusion to future scribbling on the subject. I haven't been kidding about that; there are notions simmering away for all of them.

Something that I have wanted to do since the beginning is pure science education. The first in the queue in that genre is a condensed course in genetics-- from the DNA strand to the organism-- which will no doubt be broken up into several lessons. I will then study commas, in order to divine whether I should have used such devices in the preceding two sentences (just kidding).

I have at least two articles in the hopper that are of a controversial nature. I am not afriad of controversy as such, but I refuse to make a spectacle out of it that is all sound and fury. I yearn to share knowledge with others, out there in the marketplace of ideas, so it would be foolish to scare my customers away via gratuitous... there must be a word for it, but I can't think of it. Anyway, those two are being handled gently, becuase this is a rational place-- not the Jerry Springer show.

Since it appears that there are (roughly) 524,288 excellent blogs in circulation these days, I will endeavor to link to some of them when it is appropriate to the subject matter. Why, I might even try to open a debate with another blogger at some point. (Yes, I have an idea.)

Let's see... ah, yes-- fiction. I may not read as much as I would like like, but books and other sorts of fiction will need to have their virtues and vices extolled. Bonus if I also manage to find non-fiction somewhere.

My coverage of space exploration and its attendant technologies has been pathetically little-- especially when contrasted with my large enthusiasm for the subject. I feel that my space proposals are both grand and reasonable, but I may not be the most impartial judge of that-- so that's where my highly objective viewing public comes in.

I reckon there's enough things to talk about to last a very long time. Just to use genetics as an example, once I explain the basics (unless you already know the basics), there are all sorts of neat things to discuss. Disease-causing bacteria, housecat coat patterns-- and you'd never guess how downright interesting fraternal twins in cattle can be. And then there's politics, which will no doubt always be a distraction. At any given time, there will be someone in a position of power doing something stupid. It's probably encoded in their DNA.

Posted by Mitch at 01:50 AM | Comments (0)

March 18, 2004

Ethanol Won't Save the World

Having received a request for more science (and, indeed, for new material of any sort), I decided to go to CNN.com and see what was new. And the first thing I found was:

MINNEAPOLIS, Minnesota (AP) -- Researchers say they have produced hydrogen from ethanol in a prototype reactor small enough and efficient enough to heat small homes and power cars.

Now, I applaud their ingenuity, and I favor hydrogen as the energy carrier molecule of the future. But... extracting hydrogen from ethanol as a source of energy is so utterly wrongheaded...

Wanting evidence to back up this article (which I had planned to be a righteously indignant slam of ethanol energy), I performed a quick Google search for ethanol corn energy production. I was quickly reassured that I was not the first person to look at the matter with a critical eye. By the end of the investigation, however, I had found that ethanol energy is more complicated than it seems.

Firstly, let's lay some groundwork. Ethanol-- a.k.a. grain alcohol, a.k.a. drinking alcohol-- is commonly produced from sugary or starchy feedstocks, via fermentation by yeast. The molecule is made up of two carbon, six hydrogen, and one oxygen atoms. That oxygen is related to why ethanol contains less energy per unit volume than gasoline, but also has a higher octane rating, and results in less carbon monoxide when burned. Ethanol is corrosive, and has an affinity for water, both of which make it more troublesome in gasoline blends than the competing oxygenate MTBE. (Though MTBE has political problems.)

Ethanol is an example of biomass energy, meaning that the fuel comes from living things. Modern living things, that is-- fossil fuels came from biomass originally, but their ancient origin sets them apart. Biomass energy seems like a convenient way to harness the power of the sun cleanly and efficiently, but the reality isn't as tidy-- and ethanol is the worst offender.

Every discussion of this issue seems to bring up Dr. David Pimentel, of Cornell University, who claimed that "about 70 percent more energy is required to produce ethanol than the energy that actually is in ethanol." He is rather quotable, what with statements like "Abusing our precious croplands to grow corn for an energy-inefficient process that yields low-grade automobile fuel amounts to unsustainable, subsidized food burning." (Press release here.)

The National Corn Growers Association fired back, insisting that ethanol energy was a net positive by 29%. Apparently, Dr. Pimentel had used some outdated numbers. A forgivable error, since his work with the Department of Energy was two decades ago-- but a fairly stupid one, as errors go. Dr. Pimentel's newer paper puts ethanol at a net energy loss of 29%. Naturally, most of that input energy comes from fossil fuels-- which would then seem to make ethanol useless... more on that later.

No matter which numbers you use, it clearly takes a lot of energy to produce ethanol-- and that's completely ignoring the energy input from sunlight. Why is that? Well, I'm glad you asked.

Commercial ethanol fermentation currently requires high-quality starchy feedstocks, and that means grain (the overwhleming majority comes from corn). Growing corn involves the use of large amounts of nitrogen fertilizer. Current forms of nitrogen fertilizer require a disturbing amount natural gas to produce. There are other energy costs in corn production, such as equipment fuel, but fertilizer is the big one.

There are many energy costs at the ethanol plant as well, but there is again a single large one-- that being heat for distillation, which is generally supplied by coal. Separating ethanol from water is what we scientists call "a pain." Three distillations isn't enough, in fact, and you have to resort to other tricks to get most of the remaining 5% water out.

Ethanol from corn will never be a stunningly efficient energy carrier molecule. There is a catch to all of the doom and gloom, though. Note that most of the input energy is from natural gas and coal-- both of which are extracted in large quantities in the United States. Ethanol is actually a way of transforming US fossil fuels into a liquid fuel for vehicles. It does, in fact, decrease US dependence on foreign oil-- just by a small amount.

But at what cost? Growing corn requires intensive agriculture, which has its own environmental concerns. As a former farmer, I won't tell you that growing corn is horrible, but that doesn't mean I think we should go out of our way to grow it for dubious purposes. Ethanol production involves burning coal (or natural gas, or #6 oil). Environmentalists, as a group, hate both agricultural runoff and burning coal. Thus, logically, environmentalists should vigorously oppose ethanol from corn.

It is often said that the US government's subsidization of ethanol is at least good for farmers, since it raises the price of corn. This is misleading. True, it does raise the price of corn-- but that's bad for farmers who use corn, which is nearly every farmer with animals. Comsumers of food pay higher prices either way. You're being taxed for the honor of paying more for corn-shelled, meat-filled tacos. Feel free to complain to your US senator, or to the infamous Archer Daniels Midland Corporation. Cecil Adams certainly gave ADM the treatment when he talked about ethanol.

Why do I keep specifying ethanol from corn? Well, that's because nice, starchy corn isn't the only possible feedstock for ethanol. But that's a topic for another day-- especially since such other sources are not yet ready to compete.

Speaking of alternative fuels (tm) to be discussed in my next such article, it turns out that today is National Biodiesel Day. It's Rudolf Diesel's birthday, you see. Of course, I seem to recall that Rudolf's original engine ran on coal dust, but that's just splitting hairs. =) Come on, smile.

Posted by Mitch at 11:56 PM | Comments (5)

March 04, 2004

Canadian Drug Prices, etc.

The American Association of Retired Persons (AARP) has always been concerned with the cost of health care. Logical, since AARP members consume a lot of health care goods and services. As it happens, I have access to AARP publications. When I noticed an article in the AARP Bulletin about how the Canadian system of controlling drug prices actually works, I was immediately intrigued. Of course, that was over a month ago-- and it turned out to be the June 2003 issue of the Bulletin-- but hey...

If you're a drug company marketing a new patented medicine in Canada, it seems that there are just three simple rules that the Patented Medicine Prices Review Board makes sure you follow. Well, it isn't really this simple-- but government meddling never is.

Rule #1: The price cannot be higher than that of the highest-priced (in Canada) drug used to treat the same condition.

That's right-- except under unusual circumstances, you are not allowed to price your product higher than your most expensive competitor. Your drug might cost more to make, or be more effective, but if it isn't grossly so, then the Canadian government just won't let its citizens decide whether or not to pay more for your drug.

Rule #2: For "breakthrough" drugs, which are unique and have no competitors, price cannot be higher than the median of the price for that drug charged in seven Western countries, namely Britain, France, Germany, Italy, Sweden, Switzerland, and the United States.

On 'first reading,' you might think that including the US on their list would drag the allowable price upward, but that's not really the case. The rule doesn't specify the mean (average) of the prices, but rather the median, which is the number in the middle. The median of one, two, and fifty, is two-- the actual size of the numbers is irrelevant. As long as the price in the US is above the median (and it usually is), then the price itself makes no difference.

I'll let the Bulletin help me out with this.


Almost all Western governments, except the United States, control drug prices in varying ways. Canada's system is unique. And, contrary to many assumptions, it does not simply set a price for each drug and demand that the manufacturer accept it in order to do business.

[big snip]

The review board system "has had a bigger impact on pricing than I ever anticipated," says Tom Brogan, a former Canadian civil servant who helped write the 1987 law. "It's not price control like it is, say, in France, where they come up with prices almost by edict. But it has made companies more careful of what their introductory price is."


So the geniuses in Ottawa are proud that they don't just declare a price by government fiat-- but they mandate a price that's based on other countries, some of which do exactly that. My Geiger counter is detecting idiocy particles in large quantities.

Rule #3: Over time, prices cannot be increased beyond the general rate of inflation, as reflected in Canada's Consumer Price Index.

That sounds fair. Compared to basing your prices on other countries' price controls, this makes perfect sense.

Three simple rules. Yep. We're not done yet, though. It seems that Canada's famous federal health care systems doesn't cover medications. As such, individual provinces have instituted drug coverage for citizens over age 65-- the age group well-known for its consumption of prescription drugs. The provinces decide which drugs to cover based on "value for money," so new drugs are priced lower than competitors, in order to lure the monolithic and cost-conscious government. Imagine your market share if the Ontario government chooses your drug... or doesn't, as the case may be.

Now that we know how the system works, the big question is whether nations with government price controls are getting a free lunch. I'm afraid that the answer is "yes."

So are higher American prices subsidizing the rest of the world? "When I was in government I would have said absolutely not," says Brogan, who now runs a company that advises governments, insurers and drug companies on prices. "But now I think it is. It takes money to bring a new drug to market, and somebody's got to pay for it."

Grammar aside, there's something extrememly revealing in Mr. Brogan's statements. "When I was in government I would have said absolutely not," he says. When you're holding a hammer, everything looks like a nail. When you're in government, every situation looks ripe for regulation.

It's an undeniable fact that it is very expensive to research a new drug, test it, and then get it through the FDA (or other nation's equivalent). The new drug can turn out to be a dud at many points along the way. If it does finally reach the market, you have to convince people to buy it at prices high enough to pay off not just its own costs, but also those of failed drugs.

Certain American politicians are fond of pointing out that drug companies have high profits these days, citing this as evidence that drug prices could be lower. This will frequently be accompanied by stories of senior citizens who cut their expensive pills in half to make them last longer.

Profits may be high-- but if you actually investivated the situation, I bet you'd find that those profits are being made on the so-called "blockbuster" drugs, which have a very wide market and are not life-saving. The Claritins and Nexiums are where the money is made, as squillions of people have allergies and/or heartburn. Life-saving drugs just don't have that kind of sales volume-- so even if they end up more expensive, the drug companies still can't make huge profits on them. It actually makes more economic sense for a company to develop yet another drug for acid reflux disease, than it does to work on a treatment for some obscure and deadly malady.

Now, it's true that drug companies make money on sales that fall under price controls. All that proves, though, is that the price is higher than the cost of manufacture and distribution.

My father once had a surgery while not covered by health insurance. The surgeon knocked something vaguely like 30% off of the price, leading my father to declare, 'If he can do it at that price for me, he can do it for everybody.' The presumption was that insurance companies were being bilked on surgeries covered by insurance, but that presumption was incorrect. The discounted rate was no doubt enough to pay the surgeon's incremental cost of performing the operation, since that amounts to things like paying the hospital for a room, buying a few drugs, and paying labor costs (including some of his own). In this sense, the doctor made money-- but it in no way proves that the discount rate was enough to cover other expenses, such as malpractice insurance, medical school debt, and other surgeries where the bill was never paid.

Since I broached the subject, it's an interesting coincidence that this is my father's birthday. He would have been 59.

As such, this is cancer awareness day for me-- which isn't just a hollow declaration, considering my education in biology. I may not be a research scientist yet, but I will be eventually. And, like so many people before me, I am determined to eradicate disease.

And now, on with the argument.

So, if anyone ever says that drug companies can afford to sell for lower prices in the US just because they do so elsewhere, feel free to call that person a moron. Especially since it's standard leftist-collectivist rhetoric that workers deserve a "living wage." A person obviously makes money from every hour of work, but some will argue that lower-paying jobs just aren't enought to live on. Well, selling things under price controls is exactly like that.

It costs big money to develop drugs, profits or no profits. If other nations artificially lower prices, then someone has to pick up the tab, and those someones are Americans. If we depressed prices here, too, then the cost would be in the new drugs never developed. And, for that matter, lost jobs at the drug companies. And, yes, lower profits-- which is a bad thing for common investors. Not every stockholder is a millionaire, you know.

About now (if you haven't gotten fed up with me), you're thinking, "That's great, but if drugs are too expensive, and government meddling won't solve it, then what do we do?" Glad you asked.

Part of the problem with health care in general is that people are insulated from the costs of it. Sure, they pay crushingly high insurance premiums, but the cost of goods and services is then generally low. Worse, the cost is usually in the form of a "co-pay" (similar to your 'deductible,' if this was car insurance), which is often of fixed size. So you'll pay X dollars for a prescription drug, regardless of how much it costs. Your doctor doesn't care what the drug price is, and neither do you, really. No amount of frugality on your part will change the insurance company's cost enough to make a difference, so why worry? This sounds a lot like [drum roll please] a tragedy of the commons. Funny how collectivism tends to lead to those.

I recently learned of an HMO which has a three-tiered drug coverage plan. There are three different co-pay levels, depending on the actual price of the drug. And just to be compassionate, they sometimes place a drug in a cheaper tier if there is no less expensive alternative.

There is no need to ban expensive drugs from the program, since costs still discourage people from using them. Discourage, but not prevent. The cheaper drug might not work for you, or it might be less effective in general. You are subject to market forces, and yet you still receive payment assistance from the insurance comapny. Such a system sounds like elegance, itself.

And, of course, patients who pay retail price for their prescriptions put considerable pressure on their doctors to ponder a cost/benefit analysis when writing prescriptions. In much the same way that generic drugs are quite popular.

Now, it's certainly possible that the reduction in costs (if everyone obeyed me) would reduce revenue to the drug companies. I explained earlier that they needed that money to develop new drugs. This is not a paradox, though. People voting with their feet (and money) is the stuff of honest and fruitful competition. Neither government price-reduction edicts-- nor 'competition' to be the one true supplier to a government or insurance monolith-- can possibly create such a positive economic environment.

Posted by Mitch at 01:30 AM | Comments (0)